The 1000 Mitoses Project: A Consensus-Based International Collaborative Study on Mitotic Figures Classification.

ABSTRACT: Introduction. The identification of mitotic figures is essential for the diagnosis, grading, and classification of various different tumors. Despite its importance, there is a paucity of literature reporting the consistency in interpreting mitotic figures among pathologists. This study leverages publicly accessible datasets and social media to recruit an international group of pathologists to score an image database of more than 1000 mitotic figures collectively. Materials and Methods. Pathologists were instructed to randomly select a digital slide from The Cancer Genome Atlas (TCGA) datasets and annotate 10-20 mitotic figures within a 2 mm² area. The first 1010 submitted mitotic figures were used to create an image dataset, with each figure transformed into an ind

SUBMITTER: Lin S 

PROVIDER: S-EPMC11497755 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature