Bacteriocin distribution patterns in <i>Enterococcus faecium</i> and <i>Enterococcus lactis</i>: bioinformatic analysis using a tailored genomics framework.

ABSTRACT: Multidrug-resistant Enterococcus faecium strains represent a major concern due to their ability to thrive in diverse environments and cause life-threatening infections. While antimicrobial resistance and virulence mechanisms have been extensively studied, the contribution of bacteriocins to E. faecium's adaptability remains poorly explored. E. faecium, within the Bacillota phylum, is a prominent bacteriocin producer. Here, we developed a tailored database of 76 Bacillota bacteriocins (217 sequences, including 40 novel bacteriocins) and applied it to uncover bacteriocin distribution patterns in 997 quality-filtered E. faecium and Enterococcus lactis (former E. faecium clade B) genomes. Curated using computational pipelines and literature mining, our

SUBMITTER: Tedim AP 

PROVIDER: S-EPMC11497781 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature