Phospholipid biosynthesis regulation for improving pigment production by <i>Monascus</i> in response to ammonium chloride stress.

ABSTRACT: In the actual industrial production process, the efficient biosynthesis and secretion of Monascus pigments (MPs) tend to take place under abiotic stresses, which often result in an imbalance of cell homeostasis. The present study aimed to thoroughly describe the changes in lipid profiles in Monascus purpureus by absolute quantitative lipidomics and tandem mass tag-based quantitative proteomics. The results showed that ammonium chloride stress (15 g/L) increased MP production while inhibiting ergosterol biosynthesis, leading to an imbalance in membrane lipid homeostasis in Monascus. In response to the imbalance of lipid homeostasis, the regulation mechanism of phospholipids in Monascus was implemented, including the inhibition of lysophospholipids production, mai

SUBMITTER: Jiang X 

PROVIDER: S-EPMC11497785 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature