Discovery of a novel methionine biosynthetic route <i>via O</i>-phospho-l-homoserine.

ABSTRACT: Methionine (Met), a sulfur-containing amino acid, is essential for the underlying biological processes in living organisms. In addition to its importance as a starting building block for peptide chain elongation in protein biosynthesis, Met is a direct precursor of S-adenosyl-l-methionine, an indispensable methyl donor molecule in primary and secondary metabolism. Streptomyces bacteria are well known to produce diverse secondary metabolites, but many strains lack canonical Met pathway genes for l-homocysteine, a direct precursor of Met in bacteria, plants, and archaea. Here, we report the identification of a novel gene (metM) responsible for the Met biosynthesis in Streptomyces strains and demonstrate the catalytic function of the gene product, MetM. We further

SUBMITTER: Hasebe F 

PROVIDER: S-EPMC11497804 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature