Phage-based biocontrol of <i>Porphyromonas gingivalis</i> through indirect targeting.

ABSTRACT: Bacteriophages offer an opportunity for chemical-free, precise control of problematic bacteria, but this approach can be limited when lytic phages are difficult to obtain for the target host. In such cases, phage-based targeting of cooperating or cross-feeding bacteria (e.g., Streptococcus gordonii) can be an effective approach to control the problematic bacteria (e.g., Porphyromonas gingivalis). Using a dual-species biofilm system, phage predation of S. gordonii (10⁸ PFU·mL^-1) decreased the abundance of pathogenic P. gingivalis by >99% compared with no-treatment controls, while also inhibiting the production of cytotoxic metabolic end products (butyric and propionic acids). Phage treatment upregulated genes associated with interspecies co-

SUBMITTER: Wu C 

PROVIDER: S-EPMC11497834 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature