Expression of integrin α_vβ₃ in medullary thyroid carcinoma.

ABSTRACT: Aim: Tumor markers often remain elevated after intended curative resection of medullary thyroid carcinoma (MTC). The aim of this study was to determine the expression of α_vβ₃, a promising theranostics target, in MTC and its metastases.Materials & methods: A_vβ₃ expression was analyzed in 104 patients using a tissue microarray and correlated with clinicopathological variables and survival.Results: Cytoplasmic α_vβ₃ positivity was seen in 70 patients and was associated with lymph node metastases at time of initial surgery. Membranous positivity was considered positive in 30 patients and was associated with sporadic MTC.Conclusion: A_vβ₃ was expressed in the cytoplasm of 67% of MTC

SUBMITTER: de Vries LH 

PROVIDER: S-EPMC11497997 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature