Myocardial ultrastructure of human heart failure with preserved ejection fraction.

ABSTRACT: Over half of patients with heart failure have a preserved ejection fraction (>50%, called HFpEF), a syndrome with substantial morbidity/mortality and few effective therapies¹. Its dominant comorbidity is now obesity, which worsens disease and prognosis^1-3. Myocardial data from patients with morbid obesity and HFpEF show depressed myocyte calcium-stimulated tension⁴ and disrupted gene expression of mitochondrial and lipid metabolic pathways^5,6, abnormalities shared by human HF with a reduced EF but less so in HFpEF without severe obesity. The impact of severe obesity on human HFpEF myocardial ultrastructure remains unexplored. Here we assessed the myocardial ultrastructure in septal biopsies from patients with HFpEF using transmission electron mic

SUBMITTER: Meddeb M 

PROVIDER: S-EPMC11498130 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature