An autonomous implantable device for the prevention of death from opioid overdose.

ABSTRACT: Opioid overdose accounts for nearly 75,000 deaths per year in the United States, now a leading cause of mortality among young people aged 18 to 45 years. At overdose levels, opioid-induced respiratory depression becomes fatal without the administration of naloxone within minutes. Currently, overdose survival relies on bystander intervention, requiring a nearby person to find the overdosed individual and have immediate access to naloxone to administer. To circumvent the bystander requirement, we developed the Naloximeter: a class of life-saving implantable devices that autonomously detect and treat overdose while simultaneously contacting first responders. We present three Naloximeter platforms, for fundamental research and clinical translation, all equipped with optical sensors, drug deliv

SUBMITTER: Ciatti JL 

PROVIDER: S-EPMC11498215 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature