Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina.

ABSTRACT: The phototransduction cascade enables the photoreceptor to detect light over a wide range of intensities without saturation. The main second messenger of the cascade is cGMP and the primary regulatory mechanism is calcium feedback. However, some experimental data suggest that cAMP may also play a role in regulating the phototransduction cascade, but this would require changes in cAMP on a time scale of seconds. Currently, there is a lack of data on the dynamics of changes in intracellular cAMP levels on this timescale. This is largely due to the specificity of the sensory modality of photoreceptors, which makes it practically impossible to use conventional experimental approaches based on fluorescence methods. In this study, we employed the method of rapid cryofixation of retinal samples a

SUBMITTER: Chernyshkova O 

PROVIDER: S-EPMC11498274 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature