Screening Antioxidant Components in Yiwei Decoction Using Spectrum-Effect Relationship and Network Pharmacology.

ABSTRACT: Yiwei decoction (YWD) is a classic prescription with the function of nourishing stomach yin. In this study, the effective components of antioxidant activity of YWD and its possible mechanism were discussed from the point of view of spectral effect relationship and network pharmacology. Firstly, the fingerprints of 10 batches of YWD were established by UPLC-PDA technique, and the 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) scavenging rate and total antioxidant capacity (T-AOC) were used as the indicators for antioxidant activity in vitro. Then, the spectral effect relationship between the fingerprint profiles and antioxidant capacity was analyzed through grey relational analysis (GRA) and orthogonal projections to latent structures (OPLS). In addition, network pharmacology was employed to

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11498994 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature