SPA Promotes Atherosclerosis Through Mediating Macrophage Foam Cell Formation-Brief Report.

ABSTRACT:

Background

Atherosclerosis is a progressive inflammatory disease in which macrophage foam cells play a central role in disease pathogenesis. SPA (surfactant protein A) is a lipid-associating protein involved with regulating macrophage function in various inflammatory diseases. However, the role of SPA in atherosclerosis and macrophage foam cell formation has not been investigated.

Methods

SPA expression was assessed in healthy and atherosclerotic human coronary arteries and the brachiocephalic arteries of wild-type or ApoE-deficient mice fed high-fat diets for 4 weeks. Hypercholesteremic wild-type and SPA-deficient mice fed a high-fat diet for 6 weeks were investigated for atherosclerotic lesions in vivo. In vitro experiments using RAW264.7 macrophages, primary resident peri

SUBMITTER: King SD 

PROVIDER: S-EPMC11499019 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature