Spatial Transcriptomic Approach to Understanding Coronary Atherosclerotic Plaque Stability.

ABSTRACT:

Background

Coronary atherosclerotic plaques susceptible to acute coronary syndrome have traditionally been characterized by their surrounding cellular architecture. However, with the advent of intravascular imaging, novel mechanisms of coronary thrombosis have emerged, challenging our contemporary understanding of acute coronary syndrome. These intriguing findings underscore the necessity for a precise molecular definition of plaque stability. Considering this, our study aimed to investigate the vascular microenvironment in patients with stable and unstable plaques using spatial transcriptomics.

Methods

Autopsy-derived coronary arteries were preserved and categorized by plaque stability (n=5 patients per group). We utilized the GeoMx spatial profiling platform and Whole Tran

SUBMITTER: Gastanadui MG 

PROVIDER: S-EPMC11499036 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature