Stepwise Functional Brain Architecture Correlates with Atrophy in Progressive Supranuclear Palsy.

ABSTRACT:

Background

Stepwise functional connectivity (SFC) detects whole-brain functional couplings of a selected region of interest at increasing link-step topological distances.

Objective

This study applied SFC to test the hypothesis that stepwise architecture propagating from the disease epicenter would shape patterns of brain atrophy in patients with progressive supranuclear palsy-Richardson's syndrome (PSP-RS).

Methods

Thirty-six patients with PSP-RS and 44 age-matched healthy control subjects underwent brain magnetic resonance imaging on a 3-T scanner. The disease epicenter was defined as the peak of atrophy observed in an independent cohort of 13 cases with postmortem confirmation of PSP pathology and used as seed region for SFC analysis. First, we explored SFC rearrang

SUBMITTER: Spinelli EG 

PROVIDER: S-EPMC11499047 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature