Understanding bladder cancer risk: Mendelian randomization analysis of immune cell and inflammatory factor influence.

ABSTRACT:

Introduction

The intricate roles of immune cells and inflammatory factors in cancer, particularly their association with the risk of bladder cancer, are not well understood.

Methods

This study aimed to clarify potential causal relationships between these elements and the development of bladder cancer using genome-wide association study (GWAS) summary statistics for 731 immune cell phenotypes and 91 circulating inflammatory factors (cases=2,053; controls=287,137). The primary analytical approach was Inverse Variance Weighting (IVW), supplemented by MR-Egger regression, weighted median, and weighted mode analyses. Sensitivity analyses included Cochran Q test, MR-Egger intercept test, and Leave-one-out test.

Results

The findings indicated that monocytes are positively co

SUBMITTER: Un H 

PROVIDER: S-EPMC11499096 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature