Study on the gut microbiota, HPA, and cytokine levels in infantile spasms.

ABSTRACT:

Objective

The mechanisms driving the progression of infantile spasms are not well understood. We aimed to investigate the changes and correlations of the gut microbiota, the hypothalamus-pituitary-adrenal (HPA) axis hormones, and the inflammatory cytokines in children with infantile spasms before and after treatment in order to provide a reference for future pathogenesis research.

Methods

Children with infantile spasms who were admitted to our hospital were recruited into the case group. The case group was divided into the pre-treatment group (group A, n = 14), the 2 weeks after treatment group (group B), and the 1 month after treatment group (group C). On the other hand, healthy children with the same sex ratio as the case group were recruited into the control group

SUBMITTER: You J 

PROVIDER: S-EPMC11499101 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature