Ghrelin is essential for lowering blood pressure during torpor.

ABSTRACT:

Introduction

Daily torpor is an active hypothermic phenomenon that is observed in some mammals and birds during fasting. A decrease in blood pressure has also been observed in torpor; however, there remains a lack of knowledge of the underlying mechanism. We have previously reported that ghrelin, an orexigenic hormone, has a hypothermic effect and is essential for the induction and maintenance of torpor. It is also known that the ghrelin secretion is enhanced during fasting and that ghrelin receptors are distributed in the cardiovascular system. Therefore, this study was conducted to test the hypothesis that ghrelin is actively involved in the regulation of blood pressure during torpor induction.

Methods

Male wild-type and ghrelin gene-deficient mice were generated by homolo

SUBMITTER: Matsui K 

PROVIDER: S-EPMC11499174 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature