Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells in <i>Drosophila</i>.

ABSTRACT:

Introduction

Intestinal stem cells (ISCs) are crucial for tissue repair and homeostasis because of their ability to self-renew and differentiate. However, their functionality declines significantly with age, resulting in reduced tissue regeneration and a higher risk of age-related diseases. Addressing this decline in ISC performance during aging presents a substantial challenge. The specific impact of nutrients or dietary elements on ISC adaptive resizing is urgent to explore.

Methods

Drosophila ISCs are an ideal model for studying development and aging because of their genetic richness, ease of manipulation, and similarity to mammalian tissues. As the primary mitotically active cells in the Drosophila gut, ISCs are flexible in response to dietary and stress si

SUBMITTER: Zhao L 

PROVIDER: S-EPMC11499188 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature