CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome.

ABSTRACT:

Introduction

Radioresistance remains a significant challenge in the treatment of glioblastoma multiforme (GBM), the most prevalent and lethal brain cancer in adults. Metabolic alterations are known to contribute to radioresistance by activating antioxidant responses and promoting DNA repair. However, the role of circular RNAs in this process, particularly circFOXO3, is not well understood.

Methods

In this study, we investigated the expression of circFOXO3 in glioma cells exposed to radiation and in recurrent GBM tissues. We performed knockdown and overexpression experiments in vitro and in vivo to assess the effects of circFOXO3 on radiosensitivity. Metabolomic profiling was conducted to explore the metabolic changes associated with circFOXO3 overexpression fol

SUBMITTER: Xu H 

PROVIDER: S-EPMC11499195 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature