Intranasal sensitization model of alopecia areata using pertussis toxin as adjuvant.

ABSTRACT:

Background

Nasopharyngeal Bordetella pertussis (BP) colonization is common, with about 5% of individuals having PCR evidence of subclinical BP infection on nasal swab, even in countries with high vaccination rates. BP secretes pertussis toxin (PTx). PTx is an adjuvant commonly used to induce autoimmunity in multiple animal models of human disease. Colocalization of PTx and myelin from myelinated nerves in the nasopharynx may lead to host sensitization to myelin with subsequent autoimmune pathology.

Methods

C57BL/6J female adult mice were given varied doses and schedules of intranasal PTx, MOG_35-55 antigen, or controls to test whether intranasal administration of PTx and myelin oligodendrocyte peptide (MOG_35-55) could induce experimental autoimmun

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11499204 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature