Characteristics of the vaginal microbiota and vaginal metabolites in women with cervical dysplasia.

ABSTRACT:

Introduction

Emerging evidence suggests that the vaginal microbiota is closely associated with cervical cancer. However, little is known about the relationships among the vaginal microbiota, vaginal metabolites, and cervical lesion progression in women undergoing cervical dysplasia.

Methods

In this study, to understand vaginal microbiota signatures and vaginal metabolite changes in women with cervical lesions of different grades and cancer, individuals with normal or cervical dysplasia were recruited and divided into healthy controls (HC) group, low-grade squamous intraepithelial lesions (LSIL) group, high-grade squamous intraepithelial lesions (HSIL) group, and cervical cancer (CC) group. Vaginal secretion samples were collected for 16S rRNA gene sequencing, liquid chromato

SUBMITTER: Yu T 

PROVIDER: S-EPMC11499233 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature