Glucose-regulatory hormones and growth in very preterm infants fed fortified human milk.

ABSTRACT:

Background

Bovine colostrum (BC) contains a range of milk bioactive components, and it is unknown how human milk fortification with BC affects glucose-regulatory hormones in very preterm infants (VPIs). This study aimed to investigate the associations between hormone concentrations and fortification type, birth weight (appropriate/small for gestational age, AGA/SGA), milk intake, postnatal age, and body growth.

Methods

225 VPIs were randomized to fortification with BC or conventional fortifier (CF). Plasma hormones were measured before, one and two weeks after start of fortification. ΔZ-scores from birth to 35 weeks postmenstrual age were calculated.

Results

Compared with CF, infants fortified with BC had higher plasma GLP-1, GIP, glucagon, and leptin concentrations a

SUBMITTER: Holgersen K 

PROVIDER: S-EPMC11499248 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature