Risk factors for infection and outcomes in infants with neonatal encephalopathy: a cohort study.

ABSTRACT:

Background

To determine the association between early infection risk factors and short-term outcomes in infants with neonatal encephalopathy following perinatal asphyxia (NE).

Methods

A retrospective population-based cohort study utilizing the National Neonatal Research Database that included infants with NE admitted to neonatal units in England and Wales, Jan 2008-Feb 2018.

Exposure

one or more of rupture of membranes >18 h, maternal group B streptococcus colonization, chorioamnionitis, maternal pyrexia or antepartum antibiotics.

Primary outcome

death or nasogastric feeds/nil by mouth (NG/NBM) at discharge.

Secondary outcomes

organ dysfunction; length of stay; intraventricular hemorrhage; antiseizure medications use.

Results

998 (13.7%) out of 72

SUBMITTER: Odd D 

PROVIDER: S-EPMC11499269 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature