Glucose-sensitive insulin with attenuation of hypoglycaemia.

ABSTRACT: The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes^1,2. Insulin doses must be adjusted to ensure that blood glucose values are within the normal range, but matching insulin doses to fluctuating glucose levels is difficult because even a slightly higher insulin dose than needed can lead to a hypoglycaemic incidence, which can be anything from uncomfortable to life-threatening. It has therefore been a long-standing goal to engineer a glucose-sensitive insulin that can auto-adjust its bioactivity in a reversible manner according to ambient glucose levels to ultimately achieve better glycaemic control while lowering the risk of hypoglycaemia³. Here we report the design and properties of NNC2215

SUBMITTER: Hoeg-Jensen T 

PROVIDER: S-EPMC11499270 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature