Brain-wide dynamics linking sensation to action during decision-making.

ABSTRACT: Perceptual decisions rely on learned associations between sensory evidence and appropriate actions, involving the filtering and integration of relevant inputs to prepare and execute timely responses^1,2. Despite the distributed nature of task-relevant representations^3-10, it remains unclear how transformations between sensory input, evidence integration, motor planning and execution are orchestrated across brain areas and dimensions of neural activity. Here we addressed this question by recording brain-wide neural activity in mice learning to report changes in ambiguous visual input. After learning, evidence integration emerged across most brain areas in sparse neural populations that drive movement-preparatory activity. Visual responses evolved from transient activati

SUBMITTER: Khilkevich A 

PROVIDER: S-EPMC11499283 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature