A new Neu-a syngeneic model of spontaneously metastatic HER2-positive breast cancer.

ABSTRACT: Metastatic disease results from the dissemination of tumor cells beyond their organ of origin to grow in distant organs and is the primary cause of death in patients with advanced breast cancer. Preclinical murine models in which primary tumors spontaneously metastasize are valuable tools for studying metastatic progression and novel cancer treatment combinations. Here, we characterize a novel syngeneic murine breast tumor cell line that provides a model of spontaneously metastatic neu-expressing breast cancer with quicker onset of widespread metastases after orthotopic mammary implantation in immune-competent NeuN mice. The NT2.5-lung metastasis (-LM) cell line was derived from serial passaging of tumor cells that were macro-dissected from spontaneous lung metastases after orthotopic mamm

SUBMITTER: Baugh AG 

PROVIDER: S-EPMC11499368 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature