The U-shaped association between serum osmolality and 28-day mortality in patients with sepsis: a retrospective cohort study.

ABSTRACT:

Background

Sepsis is a recognized global health challenge that places a considerable disease burden on countries. Although there has been some progress in the study of sepsis, the mortality rate of sepsis remains high. The relationship between serum osmolality and the prognosis of patients with sepsis is unclear.

Method

Patients with sepsis who met the criteria in the Medical Information Mart for Intensive Care IV database were included in the study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were determined using multivariable Cox regression. The relationship between serum osmolality and the 28-day mortality risk in patients with sepsis was investigated using curve fitting, and inflection points were calculated.

Results

A total of 13,219 patients with sep

SUBMITTER: Liang M 

PROVIDER: S-EPMC11499401 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature