Tuberculosis case fatality is higher in male than female patients in Europe: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Epidemiological TB data indicate differences in infection prevalence, progression rates, and clinical disease incidence between sexes. In contrast, evidence on sex-specific differential (post) TB case fatality in Europe has not been synthesized systematically.

Methods

We searched electronic databases and grey literature up to December 2020 for studies reporting sex-stratified TB death data for Europe. The JBI critical appraisal tools served for bias risk assessment and subgroup analyses for studying heterogeneity. Random-effects models meta-analyses enabled estimating pooled relative risks of sex-associated TB fatality. Considering associations of comorbidities and risk factors on fatality differences, we applied relative risk meta-regression.

Results

Based on

SUBMITTER: Pape S 

PROVIDER: S-EPMC11499538 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature