Accurate prediction of drug-target interactions in Chinese and western medicine by the CWI-DTI model.

ABSTRACT: Accurate prediction of drug-target interactions (DTIs) is crucial for advancing drug discovery and repurposing. Computational methods have significantly improved the efficiency of experimental predictions for drug-target interactions in Western medicine. However, accurately predicting the complex relationships between Chinese medicine ingredients and targets remains a formidable challenge due to the vast number and high heterogeneity of these ingredients. In this study, we introduce the CWI-DTI method, which achieves high-accuracy prediction of DTIs using a large dataset of interactive relationships of drug ingredients or candidate targets. Moreover, we present a novel dataset to evaluate the prediction accuracy of both Chinese and Western medicine. Through meticulous collection and prepro

SUBMITTER: Li Y 

PROVIDER: S-EPMC11499656 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature