Characterisation of myeloid cells in circulation and synovial fluid of patients with psoriatic arthritis.

ABSTRACT:

Objective

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Adding to studies focused on the role of T cells and macrophages, we sought to investigate the systemic activation of leukocytes in PsA.

Methods

We assessed the activation state of leukocyte populations, including polymorphonuclear neutrophils (PMNs) and monocyte/macrophages, in blood and synovial fluid (SF) by multicolour flow cytometry. We also evaluated the correlation between leukocyte numbers and expression of activation markers with disease activity parameters.

Results

SF PMNs showed an elevated activation state compared with blood PMNs, but a reduced activation state compared with oral PMNs of non-arthritic controls. In vitro stimulation caused SF PMNs to become further

SUBMITTER: Fine N 

PROVIDER: S-EPMC11499796 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature