Long-term mortality in patients with chronic obstructive pulmonary disease requiring acute non-invasive ventilation with and without obstructive sleep apnoea.

ABSTRACT:

Introduction

Chronic obstructive pulmonary disease (COPD)/obstructive sleep apnoea (OSA) overlap syndrome (OVS) is associated with higher mortality compared with COPD alone in stable outpatients. However, the prognosis of patients hospitalised with acute hypercapnic respiratory failure (ARF) is unclear.

Methods

In this retrospective cohort study, 124 patients with COPD and 44 patients with OVS were treated with positive airway pressure (PAP) for ARF and followed up for a median of 20.6 months (IQR 3.80-53.4). Patients treated in the emergency or intensive care units and did not continue PAP on the wards were excluded. We compared patient characteristics and overall survival.

Results

Mean (SD) age of participants was 71 (9.7) years and 51% were males. Patients with OVS

SUBMITTER: Nguyen BH 

PROVIDER: S-EPMC11499800 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature