Targeting CD93 on monocytes revitalizes antitumor immunity by enhancing the function and infiltration of CD8⁺ T cells.

ABSTRACT:

Background

Limited activation and infiltration of CD8⁺ T cells are major challenges facing T cell-based immunotherapy for most solid tumors, of which the mechanism is multilayered and not yet fully understood.

Methods

Levels of CD93 expression on monocytes from paired non-tumor, peritumor and tumor tissues of human hepatocellular carcinoma (HCC) were evaluated. The underlying mechanisms mediating effects of CD93⁺ monocytes on the inhibition and tumor exclusion of CD8⁺ T cells were studied through both in vitro and in vivo experiments.

Results

In this study, we found that monocytes in the peritumoral tissues of HCC significantly increased levels of CD93 expression, and these CD93⁺ monocytes collocated with CD8⁺ T c

SUBMITTER: Jiang D 

PROVIDER: S-EPMC11499807 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature