Clinical usefulness of digital twin guided virtual amiodarone test in patients with atrial fibrillation ablation.

ABSTRACT: It would be clinically valuable if the efficacy of antiarrhythmic drugs could be simulated in advance. We developed a digital twin to predict amiodarone efficacy in high-risk atrial fibrillation (AF) patients post-ablation. Virtual left atrium models were created from computed tomography and electroanatomical maps to simulate AF and evaluate its response to varying amiodarone concentrations. As the amiodarone concentration increased in the virtual setting, action potential duration lengthened, peak upstroke velocities decreased, and virtual AF termination became more frequent. Patients were classified into effective (those with virtually terminated AF at therapeutic doses) and ineffective groups. The one-year clinical outcomes after AF ablation showed significantly better results in the ef

SUBMITTER: Hwang T 

PROVIDER: S-EPMC11499921 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature