Oral and gut microbiome profiles in people with early idiopathic Parkinson's disease.

ABSTRACT:

Background

Early detection of Parkinson's disease (PD), a neurodegenerative disease with central and peripheral nerve involvement, ensures timely treatment access. Microbes influence nervous system health and are altered in PD.

Methods

We examined gut and mouth microbiomes from recently diagnosed patients in a geographically diverse, matched case-control, shotgun metagenomics study.

Results

Here, we show greater alpha-diversity in 445 PD patients versus 221 controls. The microbial signature of PD includes overabundance of 16 OTUs, including Streptococcus mutans and Bifidobacterium dentium, and depletion of 28 OTUs. Machine learning models indicate that subspecies level oral microbiome abundances best distinguish PD with reasonably high accuracy (area under the curve:

SUBMITTER: Stagaman K 

PROVIDER: S-EPMC11499922 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature