Dynamic Narrowing of the Diaphragmatic Vena Cava in Ovis aries.

ABSTRACT: Dorset sheep (Ovis aries) are common models in translational cardiovascular research due to physiologic and anatomic similarities to humans. While employing ovine subjects to study single-ventricle physiology, we repeatedly observed position-based changes in central venous pressure (CVP) which could not be explained by hydrostatic (gravitational) effects. Inferior vena cava (IVC) narrowing or compression has been demonstrated in numerous species, and we hypothesised that this phenomenon might explain our observations in O. aries. This study aimed to characterise position-dependent morphology of the IVC in O. aries using catheter-based hemodynamic and dimensional measurements, three-dimensional MRI reconstruction and histological analysis. Baseline measurements revealed a significant reduct

SUBMITTER: Schwartzman WE 

PROVIDER: S-EPMC11500010 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature