Causal relationship between hyperthyroidism and cataracts: a two-sample bi-directional mendelian randomization study.

ABSTRACT: Clinical studies and meta-analyses have suggested a link between thyroid dysfunction and lens opacification. The objective of this study is to investigate the causal relationship between hyperthyroidism and the development of cataracts using the Mendelian randomization approach, with the aim of filling the gap in knowledge about the systemic effects of hyperthyroidism on ocular health. Leveraging genetic variants as instrumental variables, the analysis used extensive datasets from the UK Biobank and the FinnGen Database and employed three common approaches for causal inference (the Inverse Variance Weighted method, a regression based method the Weighted Median estimator, and MR-Egger regression) and accompanying sensitivity analyses to ensure robustness. The results demonstrate that there

SUBMITTER: Ding H 

PROVIDER: S-EPMC11500179 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature