Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion.

ABSTRACT: Microglia, the resident immune cells of the central nervous system (CNS), play a major role in damage progression and tissue remodeling after acute CNS injury, including ischemic stroke (IS) and spinal cord injury (SCI). Understanding the molecular mechanisms regulating microglial responses to injury may thus reveal novel therapeutic targets to promote CNS repair. Here, we investigated the role of microglial tumor necrosis factor receptor 2 (TNFR2), a transmembrane receptor previously associated with pro-survival and neuroprotective responses, in shaping the neuroinflammatory environment after CNS injury. By inducing experimental IS and SCI in Cx3cr1^CreER:Tnfrsf1b^fl/fl mice, selectively lacking TNFR2 in microglia, and corresponding Tnfrsf1b^fl/fl littermate

SUBMITTER: Raffaele S 

PROVIDER: S-EPMC11500189 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature