Deciphering HER2-low breast cancer (BC): insights from real-world data in early stage breast cancer.

ABSTRACT:

Background

Human epidermal growth factor receptor 2 (HER2)-low has emerged as a potential new entity in breast cancer (BC). Data on this subset are limited, and prognostic results are controversial, evidencing the need of further data in a BC real-world cohort.

Methods

Patients with HER2-negative stage I-III BC diagnosed between 2006 and 2016 were retrospectively reviewed in a single cohort from the Catalan Institute of Oncology Badalona. Demographics and clinicopathological characteristics were examined via medical charts/electronic health records. We aim to describe and compare HER2-0/HER2-low populations through Chi-square or Fisher test, and explore its prognostic impact using Kaplan-Meier curves and Cox regression models.

Results

From a cohort of 1755 BC patients

SUBMITTER: Pous A 

PROVIDER: S-EPMC11500235 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature