A subset of image-defined risk factors predict completeness of resection in children with high-risk neuroblastoma: An international multicenter study.

ABSTRACT:

Background

Image-defined risk factors (IDRFs) were promulgated for predicting the feasibility and safety of complete primary tumor resection in children with neuroblastoma (NB). There is limited understanding of the impact of individual IDRFs on resectability of the primary tumor or patient outcomes. A multicenter database of patients with high-risk NB was interrogated to answer this question.

Design/methods

Patients with high-risk NB (age <20 years) were eligible if cross-sectional imaging was performed at least twice prior to resection. IDRFs and primary tumor measurements were recorded for each imaging study. Extent of resection was determined from operative reports.

Results

There were 211 of 229 patients with IDRFs at diagnosis, and 171 patients with IDRFs present

SUBMITTER: Espinoza AF 

PROVIDER: S-EPMC11500268 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature