Nasal obstruction during development leads to defective synapse elimination, hypersynchrony, and impaired cerebellar function.

ABSTRACT: Nasal respiratory disorders are linked to craniofacial anomalies and systemic dysfunctions. However, the implications of nasal respiratory disorders on brain development and their subsequent impact on brain functionalization remain largely unknown. Here, we describe that nasal obstruction from postnatal developmental stages in mice precipitates deficits in cerebellum-associated behaviors and compromised refinement and maturation of neural circuits in the cerebellum. We show that mice with nasal obstruction during developmental phases exhibit marked impairments in motor function and exhibit increased immobility time in forced swimming test. Additionally, we identified critical periods during which nasal respiration is essential for optimizing motor function and preserving mental health. Our

SUBMITTER: Tanigawa M 

PROVIDER: S-EPMC11500345 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature