Prenatal Exposure to Source-Specific Fine Particulate Matter and Autism Spectrum Disorder.

ABSTRACT: In this study, associations between prenatal exposure to fine particulate matter (PM2.5) from 9 sources and development of autism spectrum disorder (ASD) were assessed in a population-based retrospective pregnancy cohort in southern California. The cohort included 318,750 mother-child singleton pairs. ASD cases (N = 4559) were identified by ICD codes. Source-specific PM2.5 concentrations were estimated from a chemical transport model with a 4 × 4 km² resolution and assigned to maternal pregnancy residential addresses. Cox proportional hazard models were used to estimate the hazard ratios (HR) of ASD development for each individual source. We also adjusted for total PM2.5 mass and in a separate model for all other sources simultaneously. Increased ASD risk was observed wit

SUBMITTER: Luglio DG 

PROVIDER: S-EPMC11500427 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature