Heterogeneity in Dental Tissue-Derived MSCs Revealed by Single-Cell RNA-seq.

ABSTRACT: Mesenchymal stromal cells (MSCs) are multipotent, progenitor cells that reside in tissues across the human body, including the periodontal ligament (PDL) and gingiva. They are a promising therapeutic tool for various degenerative and inflammatory diseases. However, different heterogeneity levels caused by tissue-to-tissue and donor-to-donor variability, and even intercellular differences within a given MSCs population, restrict their therapeutic potential. There are considerable efforts to decipher these heterogeneity levels using different "omics" approaches, including single-cell transcriptomics. Previous studies applied this approach to compare MSCs isolated from various tissues of different individuals, but distinguishing between donor-to-donor and tissue-to-tissue variability is still

SUBMITTER: Behm C 

PROVIDER: S-EPMC11500480 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature