Molecular dissection of the chromosome partitioning protein RocS and regulation by phosphorylation.

ABSTRACT: Chromosome segregation in bacteria is a critical process ensuring that each daughter cell receives an accurate copy of the genetic material during cell division. Active segregation factors, such as the ParABS system or SMC complexes, are usually essential for this process, but they are surprisingly dispensable in Streptococcus pneumoniae. Rather, chromosome segregation in S. pneumoniae relies on the protein Regulator of Chromosome Segregation (RocS), although the molecular mechanisms involved remain elusive. By combining genetics, in vivo imaging, and biochemical approaches, we dissected the molecular features of RocS involved in chromosome segregation. We investigated the respective functions of the three RocS domains, specifically the C-terminal amphipathic helix (AH

SUBMITTER: Demuysere M 

PROVIDER: S-EPMC11500499 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature