The <i>Sinorhizobium meliloti</i> nitrogen-fixing symbiosis requires CbrA-dependent regulation of a DivL and CckA phosphorelay.

ABSTRACT: The cell cycle is a fundamental process involved in bacterial reproduction and cellular differentiation. For Sinorhizobium meliloti, cell cycle outcomes depend on its growth environment. This bacterium shows a tight coupling of DNA replication initiation with cell division during free-living growth. In contrast, it undergoes a novel program of endoreduplication and terminal differentiation during symbiosis within its host. While several DivK regulators at the top of its CtrA pathway have been shown to play an important role in this differentiation process, there is a lack of resolution regarding the downstream molecular activities required and whether they could be unique to the symbiosis cell cycle. The DivK kinase CbrA is a negative regulator of CtrA activity and is required for s

SUBMITTER: Bender HA 

PROVIDER: S-EPMC11500502 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature