Causal associations between kidney function and aortic valve stenosis: a bidirectional Mendelian randomization analysis.

ABSTRACT:

Background

Aortic valve stenosis (AVS) is currently the most common heart valve disease. The results of observational studies on the incidence of AVS in the renal dysfunction population are contradictory due to the short follow-up period and different diagnostic criteria, etc. This study aimed to explore the causal relationship between kidney function and AVS using Mendelian randomization (MR) analysis.

Methods

We acquired summary statistics of estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) from the CKDGen Consortium and a study on AVS from the FinnGen biobank. Univariate and multivariable MR analyses were conducted to evaluate the causal associations. The MR-Egger intercept and MR-PRESSO Global test were applied to assess the pleiotropic effect

SUBMITTER: Pan W 

PROVIDER: S-EPMC11500509 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature