Impact of effective refractory period personalization on arrhythmia vulnerability in patient-specific atrial computer models.

ABSTRACT:

Aims

The effective refractory period (ERP) is one of the main electrophysiological properties governing arrhythmia, yet ERP personalization is rarely performed when creating patient-specific computer models of the atria to inform clinical decision-making. This study evaluates the impact of integrating clinical ERP measurements into personalized in silico models on arrhythmia vulnerability.

Methods and results

Clinical ERP measurements were obtained in seven patients from multiple locations in the atria. Atrial geometries from the electroanatomical mapping system were used to generate personalized anatomical atrial models. The Courtemanche M. et al. cellular model was adjusted to reproduce patient-specific ERP. Four modeling approaches were compared: homogeneous (A), heteroge

SUBMITTER: Martinez Diaz P 

PROVIDER: S-EPMC11500604 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature