Facilitators and barriers to adolescent participation in a TB clinical trial.

ABSTRACT: The inclusion of adolescents in TB drug trials is essential for the development of safe, child-friendly regimens for the prevention and treatment of TB. TB Trials Consortium Study 31/AIDS Clinical Trials Group A5349 (S31/A5349) enrolled adolescents as young as 12 years old. We assessed investigator and coordinator described facilitators and barriers to adolescent recruitment, enrollment, and retention.Interviews were conducted with six investigators from sites that enrolled adolescent participants and six investigators from non-enrolling sites. Additionally, two focus groups were conducted with study coordinators from enrolling sites and two focus groups with non-enrolling sites. Discussions were transcribed,

SUBMITTER: Mangan JM 

PROVIDER: S-EPMC11500608 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature