Assessing Wolbachia-mediated sterility for dengue control: emulation of a cluster-randomized target trial in Singapore.

ABSTRACT:

Background

Matings between male Aedes aegypti mosquitoes infected with wAlbB strain of Wolbachia and wildtype females yield non-viable eggs. We evaluated the efficacy of releasing wAlbB-infected Ae. aegypti male mosquitoes to suppress dengue.

Methods

We specified the protocol of a two-arm cluster-randomized test-negative controlled trial (cRCT) and emulated it using a nationally representative test-negative/positive database of individuals reporting for febrile illness to any public hospital, general practitioner or polyclinic. We retrospectively built a cohort of individuals who reside in Wolbachia locations vs a comparator control group who do not reside in Wolbachia locations, using a nationally representative database of all individuals whom report for febrile illness an

SUBMITTER: Lim JT 

PROVIDER: S-EPMC11500660 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature