Acute brain injury and nanomedicine: sex as a biological variable.

ABSTRACT: Sex as a biological variable has been recognized for decades to be a critical aspect of the drug development process, as differences in drug pharmacology and toxicity in female versus male subjects can drive the success or failure of new therapeutics. These concepts in development of traditional drug systems have only recently begun to be applied for advancing nanomedicine systems that are designed for drug delivery or imaging in the central nervous system (CNS). This review provides a comprehensive overview of the current state of two fields of research - nanomedicine and acute brain injury-centering on sex as a biological variable. We highlight areas of each field that provide foundational understanding of sex as a biological variable in nanomedicine, brain development, immune res

SUBMITTER: Simmons A 

PROVIDER: S-EPMC11500709 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature