Human umbilical cord mesenchymal stem cells toxicity and allergy effects: In vivo assessment.

ABSTRACT:

Objective

Human umbilical cord mesenchymal stem cells (hUCMSCs) hold significant promise across various clinical applications. Therefore, regulatory requirements necessitate a thorough investigation of the hUCMSCs safety before clinical trials and potential allergic reactions after transplantation.

Methods

Abnormal toxicity test employed mice and guinea pigs dosed daily at 0.5×106 cells and 5×106 cells, respectively for 7 days. Acute toxicity test employed low, medium, and high doses of hUCMSCs injected into mice once, followed by observations for 23 days. In systemic allergy test, guinea pigs received low and high dose of hUCMSCs, with sensitization and excitation stages at day 14 and 21, respectively.

Results

The abnormal toxicity test of hUCMSC injections revealed

SUBMITTER: Cheng WD 

PROVIDER: S-EPMC11500854 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature