Comparison of efficacy and safety of different anticoagulation regimens in plasma exchange: A systematic review and meta-analysis.

ABSTRACT:

Background

Extracorporeal line clotting during plasma exchange (PE) not only delays efficient treatment, but also cause great waste of nursing resources. There is a lack of comprehensive comparison of the efficacy and safety among different anticoagulation regimens in plasma exchange in literature.

Methods

A systematic search was performed in EMBASE, MEDLINE via PubMed, Cochrane Central Library, and CNKI. Studies that had compared at least two anticoagulation regimens in PE were considered eligible. The anticoagulative efficacy outcome was assessed by the occurrence of extracorporeal circuit clotting. The safety outcome was assessed by the occurrence of bleeding events, post-treatment APTT values, and post-treatment platelets counts. The risk of bias was assessed by the AHRQ

SUBMITTER: Ren S 

PROVIDER: S-EPMC11500872 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature